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Article
August 29, 1908

EXPERIMENTS TOWARD A PHYSIOLOGICALLY ISOTONIC SOLUTION OF SALTS.

Author Affiliations

Assistant in the Theory and Practice of Physic at the Harvard Medical School: Assistant in Clinical Pathology at the Boston City Hospital. BOSTON.

From the Laboratory of the Department of Theory and Practice of Physic, and the Laboratory of Comparative Physiology, Harvard Medical School.

JAMA. 1908;LI(9):752-754. doi:10.1001/jama.1908.25410090034001l
Abstract

The solution that is almost always employed by surgeons and clinicians for irrigations and intravenous injections is the so-called normal saline solution. This is a solution of NaCl in water varying from 0.7-0.9 per cent. in strength and agreeing approximately with the tonicity of blood, that being the only property of blood which at the time that this solution was devised was sufficiently understood to be imitated. Since that time physiologists, for experimental purposes, have vastly improved this solution, taking into consideration the action of other inorganic salts, besides sodium chlorid. Nevertheless, these advances have not been utilized to any considerable extent in practical medicine. Originally this research had for its object the investigation of the possible advantages of using clinically a solution which conformed more closely to blood than the ordinary normal saline solution. Saline solutions, such as those of Ringer, Locke and others, which have replaced almost entirely

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