Since the discovery of chloroform and ether postoperative pneumonia, renalcomplications and other deleterious results, as well as the danger of death from their use, have baffled the medical fraternity, and the only apparent escape from this condition seems to be through the widespread use of nitrous oxid and oxygen.
The dentist has been so prominent in the discovery of anesthesia and has made his work so well known that this paper shall deal mostly with the surgical field. It is well to state, however, that the nasal administration of nitrous oxid combined with pure oxygen is surpassing all previous results in dental anesthesia.
Recent clinical experiments prove, beyond doubt, that this anesthetic is of great value to the surgeon and a boon to suffering humanity. The premonitory signs of danger produced by nitrous oxid and oxygen are so marked that the patient is much safer in the hands of an
REAM FK. NITROUS OXID AND OGYGEN IN DENTAL AND MAJOR SURGERY.. JAMA. 1908;LI(11):907–910. doi:10.1001/jama.1908.25410110029001g