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Probably no book has exercised a wider influence or produced a deeper impression on the minds of English-speaking physicians than Haig's work on "Uric Acid in the Causation of Disease." It is safe to say that a good share of the present generation of physicians have formed their conceptions of disease and have conducted its treatment under the influence of the ideas set forth in the former editions of this book. Its influence has extended even to the laity, so that it is not uncommon for the intelligent patient to assist the physician to a diagnosis by suggesting that it may be uric acid in his blood.
Two problems are presented by the book: 1, What is the secret of its immense influence, and 2, why does it continue to exercise this influence in spite of the fact that the theories of Haig have been largely repudiated by the scientific
Uric Acid as a Factor in the Causation of Disease.. JAMA. 1908;LI(13):1097-1098. doi:10.1001/jama.1908.02540130053015