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November 7, 1908


JAMA. 1908;LI(19):1603-1604. doi:10.1001/jama.1908.02540190041006

Studies in anaphylaxis have not only a remarkable theoretic interest but promise to produce important practical results. A number of conditions may be grouped together as having, probably, the hypersusceptibility of the organism to certain foreign substances as their basis. The best known instance of this is a sudden death in man after the injection of horse serum in the form of diphtheria antitoxin. The symptoms in the reported cases have been closely related to asthma, and it has been suggested that the offending substance acts on the respiratory center. Local vasomotor paralysis is also probably a factor and allies these conditions with others in which a sudden edema of some part of the body is a prominent symptom. Among these conditions may be classed edema of the lungs, angioneurotic edema, and possibly urticaria. The peculiar symptoms evoked by eggs in some individuals are probably instances of anaphylaxis. It has

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