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Article
August 7, 1909

ACUTE ANAPHYLACTIC DEATH IN GUINEA-PIGSITS CAUSE AND POSSIBLE PREVENTION; A PRELIMINARY NOTE

Author Affiliations

NEW YORK CITY

From the Department of Physiology and Pharmacology of the Rockefeller Institute for Medical Research.

JAMA. 1909;LIII(6):458-459. doi:10.1001/jama.1909.92550060033003a

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Abstract

The animals employed for this study were exclusively guinea-pigs which had been sensitized by a peritoneal injection of horse serum or by a subcutaneous injection of edestin (a proteid obtained from hemp seed). After a number of weeks the animals were tested. This was done by stretching them out on a suitable holder and injecting the horse serum (0.5 to 1 c.c.) or edestin (10 mg.) into a cannula inserted into the external jugular vein, recording at the same time the respiration or blood pressure or both. From the results which we have obtained we would like to call attention to the following:

1. The animals die of asphyxia. A few minutes after the intravenous injection of 0.5 to 1 c.c. of horse serum into a sensitized guinea-pig, it will be noticed that the respiration is remarkably modified: the

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