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In the following we give a brief summary of the principal results that we have obtained from a study of the distribution of antibodies in the body fluids of dogs and of their formation by the blood. The complete article will be published later.
In active immunization of dogs by a single intravenous injection of goat blood the lysin, agglutinin and opsonin for goat corpuscles reach their highest concentration in the blood. They are uniformly slightly less concentrated in the thoracic lymph and the neck lymph, while in the cerebrospinal fluid and aqueous humor only traces of the lysin and the opsonin can be detected at the height of immunity.
In dogs similarly immunized with rat blood the opsonin and agglutinin in the blood and lymphs describe parallel curves, the concentration being greatest in the blood. In the cerebrospinal fluid opsonin only is present, and, while the concentration is much lower than
HEKTOEN L, CARLSON AJ. THE DISTRIBUTION OF ANTIBODIES AND THEIR FORMATION BY THE BLOOD. JAMA. 1910;LIV(2):130–131. doi:10.1001/jama.1910.92550280001001r