Several years ago Wassermann, Neisser and Bruck1 published an article giving a method for the diagnosis of syphilis by examination of the blood. The experiments on which this method had been based were made on monkeys. Shortly thereafter appeared a brief clinical report by Detre and an extensive one by Neisser, Bruck and Schlicht, whose work had been chiefly directed toward demonstrating syphilitic antigen in extracts of blood corpuscles. These were soon followed by reports from Wassermann and Plaut, Schütze, Morgenroth and Stertz, Marie and Levaditi, Citron, Fleischmann and Butler, and others.
In the communication of Fleischmann and Butler, which was the first to appear in the English literature, the principles and technie of the serum reaction were set forth in detail, and the conclusions contained in this article in regard to diagnosis and therapy of syphilis based on the serum reaction have been confirmed by
BUTLER WJ. THE SERUM AND PRECIPITATE REACTIONS FOR SYPHILIS AND THEIR CLINICAL VALUE. JAMA. 1910;LIV(14):1114-1132. doi:10.1001/jama.1910.92550400001001c