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Article
April 2, 1910

EXPERIMENTAL EPIDEMIC POLIOMYELITIS IN MONKEYSSIXTH NOTE: CHARACTERISTIC ALTERATIONS OF THE CEREBROSPINAL FLUID AND ITS EARLY INFECTIVITY; INFECTION FROM HUMAN MESENTERIC LYMPH NODE

Author Affiliations

NEW YORK

From the Laboratories of the Rockefeller Institute for Medical Research, New York.

JAMA. 1910;LIV(14):1140. doi:10.1001/jama.1910.92550400001001j
Abstract

In our last communication,1 we pointed out that by making use of the filterable nature of the virus of epidemic poliomyelitis we had succeeded in detecting it in the nasal and pharyngeal mucosa of the monkey, from which we concluded that one path of elimination of the virus was by way of the nasal mucosa through its lymphatic connections with the pia arachnoid of the brain. On the basis of this observation, we assumed that infection in the monkey might be accomplished by the reverse route, namely, from the nasal and pharyngeal mucosa, and that this route probably represents one of those traversed by the virus in the course of spontaneous infection in man. We have made some experiments covering this point and have ascertained that when an emulsion of the spinal cord from a recently paralyzed monkey is brought into intimate contact with the scarified mucous membrane

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