June 11, 1910


JAMA. 1910;LIV(24):1922-1925. doi:10.1001/jama.1910.02550500008003

Perhaps it is as well that the time allotted to me this afternoon only permits that I should, as it were, expose before you the broad ground plan of the territory of vaccine therapy. To criticise adequately but one of the many moot points would in itself occupy more than the given period.

Thus, therefore, in the first place as the main basal principle, it may be laid down that bacterial infection is primarily local and that even when the microbes spread from the primary focus, nay even when a bacteriemia is set up, there still persist tissues of election in which alone those bacteria find conditions for active growth. We may put this otherwise and say that when bacteria gain entrance to the system they find but a limited opportunity for growth, nay indeed, they are destroyed in, if not by, the majority of the tissues. Let me afford

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