An accurate knowledge of the exact pharmacologic behavior of the drugs employed is a fundamental requisite of the best type of therapeutics. A considerable number of drugs are given as urinary antiseptics by way of the mouth. The urine is an excellent nutrient medium for microorganisms when once they are established therein; but further than this, its reaction is variable through a considerable range of mild acidity to distinct alkalinity, so that the effect of any chemical compound therein may be modified from time to time by the prevailing reaction of the secretion. The usefulness of hexamethylenamin, sold under a variety of trade names, as a urinary antiseptic is established by the consensus of a wide clinical use. The theory of its action centers in the liberation of formaldehyd from the compound on treatment with acid. The object in giving hexamethylenamin is to administer formaldehyd.
Dr. Jordan1 has reported
THE CONDITIONS FOR THE EFFECTIVE ACTION OF URINARY ANTISEPTICS. JAMA. 1912;LIX(1):38–41. doi:10.1001/jama.1912.04270070040016