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Article
August 3, 1912

THE JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

JAMA. 1912;LIX(5):372-376. doi:10.1001/jama.1912.04270080054021
Abstract

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SATURDAY, AUGUST 3, 1912 

SOME FEATURES OF ANAPHYLAXIS  The phenomena of anaphylaxis have given evidence of a power of adjustment or response of the organism to certain specific conditions little short of marvelous. The final explanation of what takes place within the tissues involved when an animal becomes sensitized by the injection of a millionth of a gram of egg-albumin still remains to be determined. It has been most baffling, to say the least, to find it possible to induce conditions of profound shock and physiologic unbalance by supposedly inert proteins in quantities far smaller than those which characterize the dosage of our most potent drugs and familiar poisons.Friedberger1 has ventured an explanation of the mechanism of these responses which has received widespread

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