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August 3, 1912

Pellagra. An American Problem.

JAMA. 1912;LIX(5):389-390. doi:10.1001/jama.1912.04270080071036

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The discovery of the wide prevalence of pellagra in the United States, particularly in the South, has in the past few years greatly augmented the literature on this, subject. The disease has been subjected to an intensive clinical study and much research has been undertaken with reference to the etiology. It cannot be said, however, that the latter feature has been greatly advanced. Up to the present the many etiologies remain merely theories. The symptomatology is better understood and at present most cases, perhaps, are diagnosed, although cases in different localities present a widely varying symptomatology. Except for the skin manifestations the pathology presents no very definite picture. In the treatment considerable progress has beenmade and when the cases come under medical management early the prognosis is often good. All of these points are brought out in the work of Niles in a clear and entertaining manner. Much of the

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