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The patient, a young man, aged 20, came under my observation shortly after Christmas, with all the classical symptoms of syphilis, including one of the largest chaneres I ever saw. I gave, intravenously, 0.6 gm. salvarsan. There was very little reaction from the injection and the patient was up in twenty-four hours feeling as well as usual. He and I were very hopeful and expected daily to see some sign of improvement. The expected improvement, however, did not develop; in fact, the symptoms gradually became worse. The chancre grew larger and became very foul. On the tenth day, I began to realize that I had to do something more for my patient; consequently, knowing that he had what I considered a mild infection of hookworms, I gave him the usual treatment, which brought forth a large number of worms. He immediately began to improve and on the fourth day said he
Dorsett TW. SYPHILIS COMPLICATED WITH UNCINARIASIS. JAMA. 1912;LIX(6):445-446. doi:10.1001/jama.1912.04270080127023