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October 26, 1912

PROTEIN METABOLISM IN LATE PREGNANCY AND THE PUERPERIUM

Author Affiliations

NEW YORK

From the Departments of Physiology and Obstetrics of Cornell University Medical College, New York.

JAMA. 1912;LIX(17):1522-1526. doi:10.1001/jama.1912.04270100290009
Abstract

This work was undertaken with a view of studying the metabolism in the last month of pregnancy and determining the value of changes shown by the partition ofthe nitrogen of the urine, as an index to the preeclamptic or the eclamptic state.

There has been tendency during the past few years to associate more closely the conditions known as pernicious vomiting of pregnancy occurring in the early months, toxemia of the middle period and eclampsia at or near term.1 A similar condition of liver necrosis has been found to exist in some cases of each of these conditions, and this has given rise to the theory that the symptoms are due to faulty metabolism. It is thought that the liver is unable properly to transform the nitrogenous bodies delivered to it by the portal circulation.

This theory has obtained so firm a foothold that to-day many obstetricians consider it

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