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A review of the subject of the albumin reaction in the sputum in pulmonary tuberculosis shows that a qualitative examination has been made by Sahli, Rogers, Raw, Fishberg, Brown and Ross and others in something over 1,000 cases. They are practically all agreed (1) that albumin is usually present in the sputum in pulmonary tuberculosis; (2) that in doubtful cases of pulmonary tuberculosis the presence of albumin in the sputum with a positive von Pirquet reaction would justify one in making a positive diagnosis; (3) that the intensity of the albumin reaction is, as a rule, proportional to the stage of the disease; (4) that albumin occurs in the sputum in certain other pulmonary affections, namely, pneumonia, edema, pleurisy with effusion, and emphysema with dilatation of the heart.
That all are agreed that the albumin reaction usually occurs in the sputum in pulmonary tuberculosis should prove its importance in the
WORKS BO. THE QUANTITATIVE EXAMINATION OF ALBUMIN IN THE SPUTUM IN PULMONARY TUBERCULOSIS. JAMA. 1912;LIX(17):1537-1538. doi:10.1001/jama.1912.04270100305015