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Article
November 16, 1912

A FILTERABLE AGENT THE CAUSE OF A SECOND CHICKEN-TUMOR, AN OSTEOCHONDROSARCOMA

Author Affiliations

NEW YORK

From the Laboratories of the Rockefeller Institute for Medical Research, New York.

JAMA. 1912;LIX(20):1793-1794. doi:10.1001/jama.1912.04270110207011
Abstract

The demonstration of the cause of a transplantable spindle-celled chicken-sarcoma1 led us last winter to a further study of tumors of the fowl. Spontaneous chicken-tumors are far from rare, and several excellent descriptions of them exist.2 In the course of ten months we obtained without difficulty about thirty various tumors in the living fowl. None of the growths was quite similar histologically to the sarcoma just mentioned, which is caused by a filterable agent, but there were two that, like it, proved transplantable,3 namely, a tumor producing true cartilage and bone (Chicken-Tumor 7) and a curious spindle-celled sarcoma (Chicken-Tumor 18). We wish here to report experiments showing that the osteochondromatous tumor is caused by a filterable agent.

The original osteochondroma appeared as a discrete mass on the breast-bone of an adult fowl. It was very hard, appeared to be of long standing, and projected symmetrically to either

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