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July 18, 1891

The Hypodermatic Use of Quinine.

JAMA. 1891;XVII(3):121. doi:10.1001/jama.1891.02410810037008

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The following communication addressed to a subscriber so fully covers the subcutaneous use of quinine, that he has asked and obtained permission to have the same published.

Dear Doctor:  —I take great pleasure in replying to your inquiry in regard to the hypodermatic employment of quinine. I generally use the sulphate, adding dilute sulphuric acid, drop for grain, then water enough to make one syringeful—25 to 30m. Sometimes a drop or two more of the acid is necessary. Five grains is the usual quantity for a syringeful, and in giving larger quantities (I usually give 10 gr.) I repeat the injection. The solution is always made as wanted, the injection made into muscle or deep connective tissue, as in the lumbar region. I have never seen an abscess or had one occur when given in this way. Usually there is some tenderness. In one case where the apothecary used strong

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