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The following communication addressed to a subscriber so fully covers the subcutaneous use of quinine, that he has asked and obtained permission to have the same published.
—I take great pleasure in replying to your inquiry in regard to the hypodermatic employment of quinine. I generally use the sulphate, adding dilute sulphuric acid, drop for grain, then water enough to make one syringeful—25 to 30m. Sometimes a drop or two more of the acid is necessary. Five grains is the usual quantity for a syringeful, and in giving larger quantities (I usually give 10 gr.) I repeat the injection. The solution is always made as wanted, the injection made into muscle or deep connective tissue, as in the lumbar region. I have never seen an abscess or had one occur when given in this way. Usually there is some tenderness. In one case where the apothecary used strong
Dock G. The Hypodermatic Use of Quinine.. JAMA. 1891;XVII(3):121. doi:10.1001/jama.1891.02410810037008