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At the meeting of the Society of East German Alienists at Jena, June 12, 1889, Dr. Hitzig, of Halle, reported some investigations which his assistant, Dr. Alt, had been making upon this subject. His attention was first called to it by observing that a dog that ate the matter vomited by another dog, to which a hypodermic injection of morphine had been administered previously, also vomited in a short time. A chemical test of the matter vomited by the first dog revealed the presence of morphine. Experiments by washing out the stomachs of dogs shortly after the hypodermic administration of the drug showed that its presence could be demonstrated in the stomach in 2¼ minutes after the injection, and that it continued to be eliminated for about an hour. If the stomach was washed out, vomiting did not take place, showing that it was a reflex phenomenon due to the
THE ELIMINATION OF MORPHINE INJECTED HYPODERMICALLY THROUGH THE STOMACH.. JAMA. 1890;XIV(14):511. doi:10.1001/jama.1890.02410140027005