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In September Dr. Simon Flexner of the Rockefeller Institute sent us a supply of Ehrlich's salvarsan (606), to be used for experimental purposes. The cases that we have selected for treatment with this remedy belong to unusual types and to those rebellious to the usual methods of treatment. The routine followed in every instance included a preliminary examination of the eyes, the nervous system, and a complete physical examination by competent specialists. Complete urinalyses, differential and leukocyte counts, and the Wassermann reaction were made before and after each injection. In a majority of the cases the injections were made according to Wechselmann's method. The Junkermann method was used in the later cases, however, following instructions from Dr. Flexner. A few of the patients treated by injections according to Wechselmann's technic required a small dose of morphin to relieve the pain. In all in whom the Junkermann method was used the
ENGMAN MF, MOOK WH, MARCHILDON JW. REPORT ON SIXTEEN SYPHILITIC PATIENTS TREATED WITH EHRLICH'S SALVARSAN (606). JAMA. 1911;LVI(2):87-91. doi:10.1001/jama.1911.02560020003002