In selecting cases for experimentation with "606" an attempt was made to choose those with demonstrable lesions and those which would best represent the various stages of the disease, excepting the meta- and parasyphilitic conditions.
The list of cases includes one with primary lesion of tonsil, one with primary lesion of penis with secondary eruption, two with maculopapular secondaries, one with ulcerating secondaries of the tonsils and vocal cords, and one with gummatous lesion of forehead. Except in one instance, an alkaline solution of the drug was injected into the buttocks according to the technic developed by Lesser.1 In this exception the same solution was injected intravenously, after being first diluted with distilled water to 200 c.c., according to Schreiber's method.2 The intragluteal injections gave very little pain at the time of administration except in one nervous individual. In every case the pain became quite severe within an
MARSHALL M. A REPORT OF SIX CASES OF SYPHILIS TREATED WITH SALVARSAN. JAMA. 1911;LVI(3):177-179. doi:10.1001/jama.1911.02560030013005