Although the correspondence is by no means complete in all the symptomatic details, it is nevertheless admittedly true that ordinary types of human diabetes quite closely resemble experimental pancreatic diabetes. Opie, in particular, has shown that diabetes in man is frequently associated with lesions of the islands of Langerhans, whereas extensive pancreatic lesions which do not involve the islands do not cause diabetes. It is frankly admitted, however, that many cases of diabetes occur in which no anatomic changes whatever can be detected in the pancreas, and that in other cases the lesions of the parenchyma plainly preponderate over those of the islands of Langerhans.
We may well admit that carbohydrate metabolism in the body is in some way bound up with the functions of the pancreas, without being able to give a final verdict whether the acinous tissue or the islands of Langerhans are the most important epithelial elements
THE ISLANDS OF LANGERHANS AND DIABETES. JAMA. 1914;LXIII(5):406-407. doi:10.1001/jama.1914.02570050042017