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February 18, 1911


Author Affiliations

Captain, Medical Corps, U. S. Army WASHINGTON, D. C.

From the Bacteriological Laboratory of the Army Medical School, Washington, D. C. Published with permission of the Surgeon-General, U. S. Army.

JAMA. 1911;LVI(7):492-495. doi:10.1001/jama.1911.02560070024008

The object of this paper is to present the results obtained by applying to sodium cacodylate the experiments which demonstrated the wonderful destructive action of salvarsan on the spirochetes of syphilis. These experiments are laid down in Ehrlich and Hata's recently issued monograph,1 and, in brief, they consist, first, of the determination of the tolerated dose of a given substance for normal rabbits, and, second, of the determination of the curative dose for rabbits infected with Spirochæta pallida. The results are expressed in the form of a ratio, C: T. Hata has shown that the ratio for salvarsan is at least 1 to 10 with a single intravenous injection.

Interest among clinicians of this country in sodium cacodylate in the treatment of syphilis seems to date from an article by Murphy,2 who gave a summary of the status of salvarsan at that time and then said:

It has

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