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March 10, 1888


JAMA. 1888;X(10):302. doi:10.1001/jama.1888.02400360018006

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Dr. Paul Snyers has recently completed a series of experiments undertaken for the purpose of controlling the experiments of Semmola on the pathogenesis of Bright's disease. He injected into dogs white of egg diluted with a small quantity of distilled water. The operations were done by means of a syringe of double the capacity of the ordinary Pravaz syringe. The syringe was carefully disinfected before each experiment, and the quantity of albumen injected varied from 4 to 5 grams per kilogram of the animal's weight. When this quantity is compared with the amount of albumen excreted daily by the kidneys in the gravest forms of nephritis, it is seen that the quantity injected into the dogs was incomparably greater than that excreted. After the animals were killed the kidneys were examined in the fresh state by congelation, and after the action of osmic acid, absolute alcohol, Müller's fluid, or boiling

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