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August 29, 1914


Author Affiliations

Director of the Research; Professor of Skin Diseases, Philadelphia Polyclinic and College for Graduates in Medicine; Assistant Professor of Physiologic Chemistry, University of Pennsylvania, Department of Medicine; Associate Professor of Physiologic Chemistry, Philadelphia Polyclinic and College for Graduates in Medicine; Professor of Pathology in the Philadelphia Polyclinic and College for Graduates in Medicine PHILADELPHIA

JAMA. 1914;LXIII(9):729-733. doi:10.1001/jama.1914.02570090015004

During the past two years we have had, through the generosity of a benefactor, the opportunity of prosecuting an inquiry into the cause and nature of psoriasis with the purpose of better enabling us to treat this prevalent and obstinate disease of the skin. This work has been carried out in specially equipped laboratories and with all possible thoroughness. Psoriasis is a disease that has been known since the days of the early Greeks, who characterized it by the name of "lepra." Despite the fact that it constitutes from 4 to 5 per cent. of all skin-diseases, the nature of the disease has remained thus far an enigma. Many theories have been advanced to explain its pathogenicity, but none has been satisfactorily demonstrated to be true. The three most prevailing views with regard to psoriasis are that (1) psoriasis is due to a parasite, (2) psoriasis is a disease resulting

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