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Article
August 29, 1914

THE RELATION OF PATHOLOGIC CONDITIONS IN THE NOSE AND THROAT TO THE ORIGIN AND TREATMENT OF HYPERTHYROIDISM

JAMA. 1914;LXIII(9):769-773. doi:10.1001/jama.1914.02570090055016
Abstract

The thyroid gland prepares an internal secretion which is not limited in its action to a single mechanism, as is the case with secretin. There is much evidence to support the belief that it acts on a wide range of tissues. Prominent among the theories of its function is that of detoxication, but the mechanism of its action in this respect is not well understood. The older theories of Notkin and Blum are no longer acceptable. The metabolic activity of the tissues in a thyroidectomized animal is below par. There is a lowered oxygen absorption, greater tolerance for carbohydrate, a lower body temperature and a diminished activity of both physical and mental processes. The whole picture is changed by the administration of thyroid extract. Poisonous substances which might seriously affect an animal in the abnormal condition following thyroidectomy may not be so dangerous to a normal animal or to one

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