August 29, 1914


JAMA. 1914;LXIII(9):786. doi:10.1001/jama.1914.02570090072024

Opium preparations have long been used in diabetes, and there is a wide-spread belief that they are frequently efficient in diminishing the excretion of sugar in this disease. Data might readily be cited from the literature of clinical medicine to show apparently advantageous results following opium medication. No satisfactory explanation has yet been furnished of the manner in which excretion of sugar is diminished. It has been suggested that the alleged beneficent influence of the drug is attributable in a general way to its well-known sedative action on the nervous system. This hypothesis contains, at least, something tangible, in view of the fact that more or less ill-defined conditions of nervous irritability have been said to produce certain types of diabetes. Now that the investigation of the sugar-content of the blood has assumed an importance as great as, if not greater than, the quantitative determination of the urinary sugar, the

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