September 5, 1914


JAMA. 1914;LXIII(10):823-824. doi:10.1001/jama.1914.02570100009003

The subdivision of protein metabolism into intermediary metabolism and tissue metabolism indicates that we to-day are in possession of a much more detailed and accurate knowledge concerning animal metabolism than was available a few years ago. The controversy between Voit and Pflüger and their followers of the past generation as to whether the protein of the food must be incorporated in the protoplasm of the tissues before it is oxidized was an unprofitable and useless controversy, because it was too far in advance of the experimental knowledge of that period. We still do not know the spatial relationship between protoplasm and food materials at the moment of oxidation. On the other hand, we no longer speak of protein metabolism as being an oxidation process at all in the sense understood by Pflüger and Voit. While protein materials like other carbonaceous food materials are of course finally oxidized in the body,

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