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June 16, 1888

VERNONIN, A NEW CARDIAC POISON.

JAMA. 1888;X(24):749. doi:10.1001/jama.1888.02400500017003

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Abstract

MM. Edouard Heckel and F. Schlagdenhauffen have recently communicated to the Académie des Sciences of Paris some facts in regard to vernonin, a new heart poison obtained from Vernonia nigritiana (known in Africa as Batiatior or Batjentjor), the root of which is used on the west coast of Africa as a febrifuge. As yet it has been impossible to obtain an alkaloid from the plant, but the alcoholic extract of the resin contains the glucoside vernonin, a white powder, slightly hygroscopic, the solution of which is pale yellow. It is only slightly soluble in ether and chloroform. The solutions, when evaporated, leave a colorless deposit of resinous appearance, which strikes a brown color with sulphuric acid, this color passing to a violet purple, and persisting for several hours.

According to Heckel and Schlagdenhauffen, when a few centigrams of the aqueous solution of the alcoholic extract are injected under the skin

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