[Skip to Content]
[Skip to Content Landing]
June 16, 1888


JAMA. 1888;X(24):749. doi:10.1001/jama.1888.02400500017003

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.


MM. Edouard Heckel and F. Schlagdenhauffen have recently communicated to the Académie des Sciences of Paris some facts in regard to vernonin, a new heart poison obtained from Vernonia nigritiana (known in Africa as Batiatior or Batjentjor), the root of which is used on the west coast of Africa as a febrifuge. As yet it has been impossible to obtain an alkaloid from the plant, but the alcoholic extract of the resin contains the glucoside vernonin, a white powder, slightly hygroscopic, the solution of which is pale yellow. It is only slightly soluble in ether and chloroform. The solutions, when evaporated, leave a colorless deposit of resinous appearance, which strikes a brown color with sulphuric acid, this color passing to a violet purple, and persisting for several hours.

According to Heckel and Schlagdenhauffen, when a few centigrams of the aqueous solution of the alcoholic extract are injected under the skin

First Page Preview View Large
First page PDF preview
First page PDF preview