March 11, 1916


JAMA. 1916;LXVI(11):816-817. doi:10.1001/jama.1916.02580370036019

New growths, to all intents and purposes the equivalent of malignant tumors in man, occur in many animals. There are points in connection with some growths of this kind in animals which suggest that they may be of infectious nature. By way of illustration may be mentioned the remarkable chicken sarcoma studied by Peyton Rous, apparently perfectly sterile and cell-free filtrates of the tissue of which, when injected into chickens, produce sarcomatous growths identical with the original growth. What could be more reasonable than to conclude that this growth is caused by a filterable virus, and that it is an infectious growth? The "virus" in question, however, does not correspond to other living viruses in all characteristics; it has not been possible to secure any evidence that it multiplies independently of the tumor cells, and there are no indications that the growths from which it is obtained ever spread by

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