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Article
October 17, 1914

NERVOUS AND MENTAL DISTURBANCES FOLLOWING CASTRATION IN WOMEN

Author Affiliations

PHILADELPHIA

From the Pennsylvania Epileptic Hospital and Colony Farm and the Department of Neurology of the University of Pennsylvania.

JAMA. 1914;LXIII(16):1345-1348. doi:10.1001/jama.1914.02570160011003
Abstract

It is a very well-known fact that ovarian tissue has a certain influence on the development of the body. Removal of the tissue before puberty arrests or prevents the development of the uterus; removal after puberty prevents menstruation. Removal of it is followed by atrophy of the breasts and arrest of general physical development. On the other hand, after removal of ovaries, anatomic changes have been observed in other glands, namely, hypophysis, thyroid, adrenals. In the hypophysis, for example, there is an increase of its size (hypertrophy) with an extraordinary number of eosinophilic cells and dilatation of its blood-vessels.1 Goldstein2 has recently reported a case of acromegaly which developed after castration. In the thyroid there is an increase of the acini, also dilatation of the follicles and increase of the colloid substance.3 In the adrenals hypertrophy has been observed by many authors. The same histologic modifications which

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