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Article
October 17, 1914

THE ENTRANCE OF THE INFECTIVE AGENT OF EPIDEMIC POLIOMYELITIS INTO THE BODY

JAMA. 1914;LXIII(16):1396. doi:10.1001/jama.1914.02570160062024
Abstract

For only five years have we definitely known that anterior poliomyelitis must be classed among the acute infectious diseases. In 1909 Landsteiner and Popper reported the successful inoculation of monkeys with the disease, using for inoculation material an emulsion of the spinal cord of a patient who had died in the early stages of the disease.

Since then, notably through the researches of Flexner and his associates in this country, and of Landsteiner, of Levaditi, of Kling, Wernstedt and Petterson and of Römer abroad, many additions have been made to our knowledge of the disease. Especially is this true concerning the nature of the virus, the morbid anatomy and histology of the natural as well as the experimental disease, and the routes by which the virus escapes from the body.

Of especial importance has been the announcement by Noguchi and Flexner of the successful cultivation of the causative organism by

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