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October 13, 1888


JAMA. 1888;XI(15):522-524. doi:10.1001/jama.1888.02400670018002

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Local Anæsthetic Effects of Helleborein.—V. Venturini and E. Gasparini, working in the laboratory of Professor Buffalini, at Siena, recently made the discovery that helleborein had a local anæsthetic effect. A communication on the subject was made on March 9 by Prof. Buffalini to the Società tra i Cultori delle Scienze Mediche, of Siena. The physiological effects of helleborein and helleborin were already partly known by the experiments of Schroff, Dragendorff, Marmé, Santoliquido and Paul. Santoliquido recently contemplated an investigation of the influence of these two glycosides on the heart. The local anæsthetic effects of these two substances, however, had been quite unknown hitherto. The following is a summary of the observations of Venturini and Gasparini: On the instillation of some drops of a solution of helleborein into the conjunctival sac of rabbits, complete anæsthesia of the cornea came on after fifteen minutes. Pricking with a needle was not felt by

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