Recently we commented3 on the use of sodium as compared with potassium salts, and noted that in most cases potassium salts are given not for their potassium content but for the therapeutic effects produced by the negative or acid radical, as for instance in the case of acetates, tartrates, carbonates, bicarbonates, iodids, etc. We stated also that probably the corresponding sodium salts might prove equally and sometimes even more serviceable since the sodium ion has a less depressing action on the heart and central nervous system than has the potassium ion.
In the case of such salts as quinin arsenate4 and ferric arsenate,5 the reports of the Council on Pharmacy and Chemistry have emphasized that both the acid radical and the basic group are therapeutically active. Not enough of one of the constituents of these can be given without perhaps a dangerous overdose of the other constituent.
THE ACTION OF IODIDS ON THE BLOOD-VESSELS AND HEART. JAMA. 1914;LXIII(20):1767-1768. doi:10.1001/jama.1914.02570200061023