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Article
May 13, 1916

EARLY DIAGNOSIS OF A CASE OF MYXEDÈME FRUSTE

JAMA. 1916;LXVI(20):1549. doi:10.1001/jama.1916.02580460025010

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Abstract

Several years ago Hertoghe of Belgium described an incomplete form of myxedema which he called "myxedème fruste." This condition, commonly found among women, is considered by some merely as a temporary or permanent state of thyroid insufficiency, by others as an incipient or abortive form of true myxedema; while Hertoghe looks on it as a clinical entity. A case of this kind recently came under my observation. The early recognition of the condition, the seemingly classical grouping of the signs and symptoms and the very prompt response to treatment, warrant, I believe, a report of the case.

Mrs. L. W., aged 28, came to me, Oct. 1, 1915, complaining of headaches. Inquiry into her family history revealed nothing except that one sister died of tuberculosis. Her past history was negative. Up to the date of her marriage, one year and a half previously, her menses had been regular. Nine months

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