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May 13, 1916


JAMA. 1916;LXVI(20):1550. doi:10.1001/jama.1916.02580460026011

Removal of the sexual glands produces profound changes in the organism, evidenced as alterations of bodily physique and of temperament. If the extirpation is made at an early period in life, the so-called secondary sexual characters may fail to exhibit themselves in the usual manner, and thus occasion the retention of infantile characteristics in place of typical features of adult form and behavior.1 There is reason to believe that we may properly speak of "genital hormones" at the present time, in explanation of the undoubted chemical correlation exerted by the genital glands on other parts of the reproductive apparatus as well as on the organism in general. At any rate, the secondary sexual characters must be associated with the influence of chemical substances produced by the ovary and testis, respectively. Castration after puberty cannot modify profoundly the development of structures like the skeleton, which are already completed; but it

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