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Article
May 13, 1916

THE VOLUME OF THE BLOOD AND ITS PLASMA

JAMA. 1916;LXVI(20):1550-1552. doi:10.1001/jama.1916.02580460026012
Abstract

A knowledge of the total volume of the circulating fluid in the body ought to be of considerable value, not only as one of the physiologic constants which science may be expected to establish in relation to the human organism, but also because of the important part which it may play in certain pathologic considerations. An appreciation of the absolute quantity of the blood has a bearing on the interpretation of such conditions as anemia and diseases of the heart. The possible part played by undue blood volume in cases of arterial hypertension at once suggests itself, for one naturally asks whether or not an increase in the blood mass with overfilling of the vascular system is in any way responsible for the condition. Enlarged hearts also raise the question as to the possible relation of an exceptionally large blood volume to the genesis of a situation sometimes marked by

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