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In a recent number of the LancetDrs. Thomas Stevenson and L. C. Wooldridge record some experiments made to determine whether saccharin is poisonous or not when given in excessive quantities; and if it is not poisonous under these or other conditions, whether its use in moderation interferes with the digestive processes, so as to render it advisable to forbid its use as a substitute for sugar. Saccharin is not a food in any sense; but it is recognized that there are many circumstances under which it is necessary to have a sweetening agent to take the place of sugar. As to the non-toxic nature of saccharin the experimenters have no doubt, since their experiments confirm those of reliable investigators on the Continent. Saccharin has decided antiseptic properties, and in sufficient quantities is capable of stopping the action of organized ferments. As regards its extracorporeal action on the soluble
THE DIETETIC USE OF SACCHARIN.. JAMA. 1888;XI(24):849. doi:10.1001/jama.1888.02400750021005