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Article
November 28, 1914

CHANGES IN THE ADRENAL GLAND IN DISEASE

JAMA. 1914;LXIII(22):1955-1956. doi:10.1001/jama.1914.02570220065024
Abstract

The large amount of discussion regarding the structure and function of the adrenal glands and the rôle they play in various diseases has given rise, on the whole, to conclusions which have been rather contradictory. According to Elliott,1 the normal amount of epinephrin in the glands as estimated by various observers has been too low, owing either to faulty technic or to failure to take into account the rapid post-mortem loss of the substance. Usually this loss amounts to from 10 to 15 per cent. in eighteen hours, a considerable factor which must be taken into account in drawing conclusions from post-mortem material. The adrenal of a normal adult man should weigh from 4 to 5 gm. and should contain from 4 to 5 mg. of epinephrin. Conditions of fright, anesthesia, cerebral injury, bacterial intoxications, etc., have been found to exhaust the store of epinephrin in animals through the

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