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June 3, 1916


Author Affiliations

St. Joseph, Mo.

JAMA. 1916;LXVI(23):1778. doi:10.1001/jama.1916.02580490026010

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Oppenheim says that 80 per cent, of cases of syphilis can be aborted if treatment is begun in the early stage of the chancre, three or four weeks after infection, when spirochetes are positive, the Wassermann test negative, and no glandular enlargement and chancre can be excised. If the chancre is not excised, only 30 per cent, can be aborted. The abortive treatment consists of four injections of salvarsan and twelve injections of mercuric salicylate given weekly.

For the past two years I have used the following combination to destroy the chancre when excision is not possible: calomel, 10 parts; zinc sulphate, 10 parts, and chlorin water, 50 parts. The combination has a selective action on the chancre, rendering the entire chancre necrotic, and has no effect on the healthy tissue. It is applied on a pledget of cotton and covered with the prepuce or a piece of oiled silk

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