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January 2, 1915


JAMA. 1915;LXIV(1):59. doi:10.1001/jama.1915.02570270061020

The outbreak of the great pneumonic plague in Manchuria a few winters ago afforded the first larger opportunity to study the pathologic anatomy of this disease and to examine histologically the lesions that are produced by it. To the earlier reports and particularly to those of the American investigators, Strong, Crowell and Teague,1 are now added the notes collected by Dr. Wu Lien-Teh, director and chief medical officer of the North Manchurian Plague Prevention Service, and Prof. G. Sims Woodhead of the University of Cambridge, England.2 They believe that the specimens examined by them afford evidence of the presence of an extremely acute septicemic condition in pneumonic plague. The heart is evidently affected by very active toxins. The liver shows typical examples of lesions produced by specific infective micro-organisms that give rise to toxic substances. The epithelium of the kidneys is modified by a similar toxic activity. It

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