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July 29, 1916


JAMA. 1916;LXVII(5):357-358. doi:10.1001/jama.1916.02590050035013

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Marked advances in the diagnosis of organic nervous diseases have been made in the past few years. This is in a great measure due to the careful and frequent studies of the spinal fluid in our obscure neurologic cases. The importance of Nonne's four tests, to which may be added a fifth, Lange's colloidal gold test, are demonstrated in the following case. The combination of cerebrospinal syphilis with pneumococcic meningitis seemed of sufficient interest for publication.

A woman, aged 21, single, domestic, with negative family and personal history, except for an appendectomy in 1911, stated that about two years ago she had a sore on her hand, which the doctor pronounced a gonorrheal infection. Syphilis was denied. The present complaint began about Jan. 10, 1915, when the patient developed an abscess on her right thumb which was very painful. This continued to suppurate slightly for one week, and January 17

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