January 16, 1915


JAMA. 1915;LXIV(3):242-246. doi:10.1001/jama.1915.25710290004014


DRUGS WHICH ACT ON THE CENTRAL NERVOUS SYSTEM  We may consider the drugs of these groups with reference to the dominant action, whether it be stimulation or depression, and with reference to the part of the nervous system on which they exert the most pronounced effect. The action of a drug is never limited to one part of the nervous system; though in a given case it may be exerted mainly on the brain or medulla. Few drugs produce stimulation without some subsequent depression, or depression without at least fleeting stimulation.Drugs which act mainly on the central nervous system will be classified as follows:A. Stimulants: 1. Drugs acting mainly on the spinal cord, but having important actions on the medulla (strychnin group).2. Drugs acting mainly on the medulla, but having important actions on the brain or cord (atropin group).3. Drugs acting mainly on the brain,

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