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August 5, 1916


Author Affiliations


From the Laboratory of Ophthalmological Pathology, in the Department of Surgery, Washington University Medical School.

JAMA. 1916;LXVII(6):414-418. doi:10.1001/jama.1916.02590060014004

Since ophthalmic thermotherapy is in an indefinite state, and the beneficial or harmful effects of heat on the eye are moot questions among ophthalmologists, it is desirable to make an exact study of the effects of heat when applied to the eye in various conditions of health and disease.

In order that the study may be exact, the following preliminaries must be satisfied:

  1. The devising of some simple, convenient means of applying constant, measured quantities of heat directly to the corneal or scleral surfaces for measured lengths of time.

  2. The determining by experiment on animals of the physiologic limit of heat tolerance for stated lengths of time. The physiologic limit of heat tolerance will be defined as the maximum temperature at which tissues may be held for stated lengths of time without permanently harmful effects.

  3. The application of physiologic limits to various pathologic conditions (infections, etc.), and

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