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Article
February 27, 1915

THE ABDERHALDEN REACTION

Author Affiliations

NASHVILLE, TENN.

From the Department of Pathology, Vanderbilt University Medical Department.

JAMA. 1915;LXIV(9):735-736. doi:10.1001/jama.1915.02570350029009
Abstract

During the past year considerable doubt has been cast on the specificity of the Abderhalden reaction. Abderhalden assumes that specific ferments capable of attacking only placental tissue are elaborated as the result of the entrance of placental cells into the general circulation. He used two methods of demonstrating the digestion of the placental tissue by the serum of pregnant women; the first method was by means of the polariscope, and the second, by means of dialyzing membranes. The second is the one he recommends for clinical purposes. According to this method, the serum and specially prepared placental tissue are introduced into a dialyzing thimble, and the thimble then placed in distilled water. The mixture is placed in the incubator, and the fluid outside the thimble tested the following day for the presence of substances reacting with ninhydrin. The latter substances are supposedly derived from the placental protein as a result

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