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Article
February 27, 1915

PRACTICAL PHARMACOLOGY

JAMA. 1915;LXIV(9):740-742. doi:10.1001/jama.1915.25710350001014
Abstract

VIII 

B. DEPRESSANTS: 5. OF THE HEAT CENTERS—(Continued) 

Antipyretics and Analgesics 

ACETANILID, ANTIPYRIN AND PHENACETIN GROUP  The introduction of the antipyretics and analgesics of this group affords one of the most interesting chapters of medical history. The high cost of quinin, which resulted in its adulteration, led to efforts to discover a method of preparing it synthetically, and in addition to the cost of the alkaloid, its bitter taste, and its relative insolubility, which interfered with its use by subcutaneous injection, served as a stimulus in the search for a substitute for it. While these efforts were unsuccessful so far as the immediate aims were concerned, they did lead to the discovery of numerous synthetic compounds, including the antipyretic analgesics which have come into use during the past thirty years. Curiously, the best drugs of this group were among the earliest discovered, and the exploitation of the newer members has

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