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February 27, 1915


JAMA. 1915;LXIV(9):746-747. doi:10.1001/jama.1915.02570350040019

Complete anatomic and functional regeneration of fibers in the peripheral nervous system has been demonstrated, but as regards fibers of the central nervous system, complete regeneration has been regarded as doubtful. From recent work, however, there is evidence that both in experiment and in pathologic conditions a marked attempt at regeneration of central fibers takes place. Without going into an extended consideration of the exact manner of regeneration of the fibers, a review of some of the work which has led many to believe this possible may be of interest. Perrero1 regards the question of regeneration of fibers in the central nervous system as settled now that it is possible by efficient staining methods definitely to distinguish axis cylinders from glia fibrils. He examined the cord of a man dying twenty-nine days after fracture of the fifth and sixth cervical vertebrae; there was complete softening of the cord in

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