In a recent publication,1 we set forth the results of our findings with respect to the early involvement of the nervous system in secondary syphilis. In the paper referred to, it was found that between 60 and 70 per cent, of all cases of syphilis which progress to the secondary period show some change in the spinal fluid indicative of participation of the nervous system. These studies are being continued, and we now feel that our figures at that time were conservative and that in all probability every case of syphilis which reaches the secondary period has more or less involvement of the cerebrospinal axis. Certainly, in each case, the brain, cord and meninges, together with the other systems, receive their quota of the treponeme from the blood stream.
In the continuation of our studies, we have had the opportunity of studying a number of cases of syphilis in
WILE UJ, STOKES JH. INVOLVEMENT OF THE NERVOUS SYSTEM DURING THE PRIMARY STAGE OF SYPHILIS. JAMA. 1915;LXIV(12):979-982. doi:10.1001/jama.1915.02570380027008