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March 20, 1915


JAMA. 1915;LXIV(12):1001-1002. doi:10.1001/jama.1915.02570380049019

The problem of true fatty degeneration, as contrasted with the fatty infiltration of organs, long ago resolved into the question whether or not fat can be formed directly from protein in tissue cells. If the proof of the latter transformation is forthcoming, the chemistry of possible fatty degeneration will be more clearly understood, and, conversely, the unimpeachable demonstration of actual fatty degeneration must be accepted as strong evidence of the ability of an organism to produce fat out of protein. The story of the shifting views which have been held on this subject from year to year, the supposed proofs of the validity of each contention, the successive disillusionments and counter-proofs, the battles of words reinforced by conflicting experimental evidence — all of this forms one of the interesting chapters in the progress of the medical sciences. The following summary, will, we believe, be accepted as a fair statement of

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