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This study, first presented as a thesis to the University of Edinburgh for the degree of M.D., in July, 1911, contains much valuable material and deserves to appear as a separate brochure. After giving a brief historical summary of the subject of general paresis, and paying due attention to the histopathologic researches of Nissl and Alzheimer, as well as to the introduction of the cytologic examination of the cerebrospinal fluid, the author concludes that the diagnosis of general paresis must be made only after careful macroscopic and microscopic examination according to the most modern methods. Accordingly, he makes use of nineteen cases thus studied and classifies them in four groups. In Group 1 he places cases of general paralysis with focal symptoms on the basis of vascular disorder. Group 2 treats of the cases of general paralysis with focal symptoms on the basis of localized severity of the process of
Focal Symptoms in General Paralysis.. JAMA. 1915;LXIV(12):1021. doi:10.1001/jama.1915.02570380069041