[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 54.158.119.60. Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Article
May 15, 1915

ACUTE LYMPHATIC LEUKEMIA

Author Affiliations

BALTIMORE

From the Department of Clinical Pathology and Experimental Medicine of the College of Physicians and Surgeons.

JAMA. 1915;LXIV(20):1630-1633. doi:10.1001/jama.1915.02570460006002
Abstract

In 1910 Fraenkel and Much1 pointed out that peculiar granular bacilli may be demonstrated in the glands of patients in cases of Hodgkin's disease by "reinforced" gram-staining. These bacilli, which closely resemble the granular type of the tubercle bacillus, like them are resistant to antiformin (alkaline hypochlorite solution). Unlike the latter, however, they are not acidfast, and do not give rise to tuberculous lesions in laboratory animals. In their first communication the writers report on the presence of these organisms in twelve of thirteen cases, of which eleven were definitely known to be uncomplicated by tuberculosis. In a subsequent communication Fraenkel2 states that he obtained corresponding findings in four additional cases. He concludes that Hodgkin's disease (lymphomatosis granulomatosa) is in all probability an infectious disease produced by the micro-organism in question, which may be related to, but is not identical with, the tubercle bacillus. Regarding the morphology of

First Page Preview View Large
First page PDF preview
First page PDF preview
×